DNA Glycosylase
DNA Glycosylase
The base excision repair machinery protects DNA in cells from the damaging effects of oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form of small chemical modifications. DNA glycosylases play a key role in the elimination of such DNA lesions; they recognize and excise damaged bases, thereby initiating a repair process that restores the regular DNA structure with high accuracy. All glycosylases share a common mode of action for damage recognition; they flip bases out of the DNA helix into a selective active site pocket, the architecture of which permits a sensitive detection of even minor base irregularities. Accordingly, cells lacking DNA glycosylase functions generally show increased levels of base damage in their DNA, elevated mutation rates, and hypersensitivity to specific DNA damaging agents[1][2][3].
References:
- [1]. Jacobs AL, et, al. DNA glycosylases: in DNA repair and beyond. Chromosoma. 2012 Feb;121(1):1-20. [Content Brief]
- [2]. Hossain AA, et, al. DNA glycosylases provide antiviral defence in prokaryotes. Nature. 2024 May;629(8011):410-416. [Content Brief]
- [3]. Mullins EA, et, al. Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway. Trends Biochem Sci. 2019 Sep;44(9):765-781. [Content Brief]
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DNA Glycosylase Related Products (6)
Related Products (6)
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OGG1-IN-08
0 ImagesOGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1.
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Endonuclease VIII
0 ImagesCat. No.: HY-E70575CAS No.: 118390-70-8Endonuclease VIII is a DNA repair enzyme that excises oxidized pyrimidines from DNA. Endonuclease VIII is a bacterial DNA glycosylase/AP lyase that excises modified pyrimidines, including thymine glycol (Tg), uracil glycol, dihydrothymine, dihydrouracil (DHU).
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TDG-IN-1
0 ImagesCat. No.: HY-181440CAS No.: 3092641-80-7TDG-IN-1 is an orally active, selective small-molecule inhibitor of thymine DNA glycosylase (TDG) with a Ka of 1.46 nM. TDG-IN-1 impairs the DNA-binding ability of TDG, induces downregulated expression of DHX9, accumulation of double-stranded RNA, and activation of the RIG-I/MDA5-MAVS pathway, while acting as a tumor suppressor, innate immune activator and immunostimulant. TDG-IN-1 inhibits the growth of p53-deficient tumor cells and xenograft tumors, and exerts a synthetic lethal effect with p53. TDG-IN-1 is applicable to the research of p53-deficient cancers.
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T4 Endonuclease V
0 ImagesCat. No.: HY-E70578CAS No.: 52227-85-7T4 Endonuclease V is a dual-activity DNA glycosylase that combines the activities of DNA N-glycosylase and AP lyase. T4 Endonuclease V can repair ultraviolet (UV)-induced cyclobutane pyrimidine dimers in DNA.
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OGG1 activator-1
0 ImagesCat. No.: HY-179014OGG1 activator-1 (Compound 30) is a selective 8-oxoguanine DNA glycosylase-1 (OGG1) activator with an AC50 value of 0.58 μM. OGG1 activator-1 does not activate nor inhibit the key downstream repair enzyme APE1, and shows > 150-fold selectivity for the activation effect on OGG1. OGG1 activator-1 exhibits extremely high metabolic stability and almost no cytotoxicity. OGG1 activator-1 can be used for the study of oxidative stress-related diseases (such as neurodegenerative diseases, fibrotic diseases, cancer, inflammation, etc.).
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Topoisomerase IV-IN-3
0 ImagesCat. No.: HY-181820Topoisomerase IV-IN-3 is a Staphylococcus aureus Topoisomerase IV inhibitor, DNA gyrase inhibitor and antibacterial agent. Topoisomerase IV-IN-3 has IC50 values of 1.32 μM and 0.48 μM against topoisomerase IV, and 0.88 μM and 0.54 μM against DNA gyrase. Topoisomerase IV-IN-3 inhibits decatenation, ATPase, and supercoiling activities of its target enzymes. Topoisomerase IV-IN-3 exerts antibacterial activity against Gram-positive and Gram-negative bacterial strains. Topoisomerase IV-IN-3 exhibits low cytotoxicity toward human fibroblast cells. Topoisomerase IV-IN-3 can be used for the research of bacterial infections.
